Category Archives: inspiring

Cantos XVII, XVIII, XIX, and XX

“LO! the fell monster with the deadly sting!
Who passes mountains, breaks through fenced walls
And firm embattled spears, and with his filth
Taints all the world!”  Thus me my guide address’d,
And beckon’d him, that he should come to shore,
Near to the stony causeway’s utmost edge.

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Cantos IVX, XV, XVI

SOON as the charity of native land
Wrought in my bosom, I the scatter’d leaves
Collected, and to him restor’d, who now
Was hoarse with utt’rance.  To the limit thence
We came, which from the third the second round
Divides, and where of justice is display’d
Contrivance horrible.  Things then first seen
Clearlier to manifest, I tell how next
A plain we reach’d, that from its sterile bed
Each plant repell’d. The mournful wood waves round
Its garland on all sides, as round the wood
Spreads the sad foss.  There, on the very edge,
Our steps we stay’d.  It was an area wide
Of arid sand and thick, resembling most
The soil that erst by Cato’s foot was trod.

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If by Rudyard Kipling

If you can keep your head when all about you
Are losing theirs and blaming it on you;
If you can trust yourself when all men doubt you,
But make allowance for their doubting too:
If you can wait and not be tired by waiting,
Or, being lied about, don’t deal in lies,
Or being hated don’t give way to hating,
And yet don’t look too good, nor talk too wise;

If you can dream—and not make dreams your master;
If you can think—and not make thoughts your aim,
If you can meet with Triumph and Disaster
And treat those two impostors just the same:.
If you can bear to hear the truth you’ve spoken
Twisted by knaves to make a trap for fools,
Or watch the things you gave your life to, broken,
And stoop and build’em up with worn-out tools;

If you can make one heap of all your winnings
And risk it on one turn of pitch-and-toss,
And lose, and start again at your beginnings,
And never breathe a word about your loss:
If you can force your heart and nerve and sinew
To serve your turn long after they are gone,
And so hold on when there is nothing in you
Except the Will which says to them: “Hold on!”

If you can talk with crowds and keep your virtue,
Or walk with Kings—nor lose the common touch,
If neither foes nor loving friends can hurt you,
If all men count with you, but none too much:
If you can fill the unforgiving minute
With sixty seconds’ worth of distance run,
Yours is the Earth and everything that’s in it,
And—which is more—you’ll be a Man, my son!

Cantos XI, XII, and XIII

UPON the utmost verge of a high bank,
By craggy rocks environ’d round, we came,
Where woes beneath more cruel yet were stow’d:
And here to shun the horrible excess
Of fetid exhalation, upward cast
From the profound abyss, behind the lid
Of a great monument we stood retir’d,

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Cantos IIX, IX, and X

MY theme pursuing, I relate that ere
We reach’d the lofty turret’s base, our eyes
Its height ascended, where two cressets hung
We mark’d, and from afar another light
Return the signal, so remote, that scarce
The eye could catch its beam.  I turning round
To the deep source of knowledge, thus inquir’d:
“Say what this means?  and what that other light
In answer set?  what agency doth this?”
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Gene Therapy Cures Diabetic Dogs In Only One Shot | Popular Science

Gene Therapy Cures Diabetic Dogs In Only One Shot | Popular Science.

Diabetes is associated with severe secondary complications, caused largely by poor glycemic control. Treatment with exogenous insulin fails to prevent these complications completely, leading to significant morbidity and mortality. We previously demonstrated that it is possible to generate a “glucose sensor” in skeletal muscle through co-expression of glucokinase (Gck) and insulin (Ins), increasing glucose uptake and correcting hyperglycemia in diabetic mice. Here, we demonstrate long-term efficacy of this approach in a large animal model of diabetes. A one-time intramuscular administration of adenoassociated viral vectors of serotype 1 (AAV1) encoding for Gck and Ins in diabetic dogs resulted in normalization of fasting glycemia, accelerated disposal of glucose after oral challenge, and no episodes of hypoglycemia during exercise for >4 years after gene transfer. This was associated with recovery of body weight, reduced glycosylated plasma proteins levels, and long-term survival without secondary complications. Conversely, exogenous insulin or gene transfer for Ins or Gck alone failed to achieve complete correction of diabetes, indicating that the synergistic action of Ins and Gck are needed for full therapeutic effect. This study provides the first proof-of-concept in a large animal model for a gene transfer approach to treat diabetes.